Local protein synthesis in neurons
نویسندگان
چکیده
منابع مشابه
Local protein synthesis in neurons
are likely to be harmful and prevented from spreading in the population by natural selection. This implies no functional importance for an Alu sequence itself, but merely that, as the deletions of Alus are very unlikely to be precise, a deletion event removing an Alu is also likely to remove valuable sequences around it, and the chromosome bearing the deletion will be lost by selection. The exp...
متن کاملDynamic Visualization of Local Protein Synthesis in Hippocampal Neurons
Using pharmacological approaches, several recent studies suggest that local protein synthesis is required for synaptic plasticity. Convincing demonstrations of bona fide dendritic protein synthesis in mammalian neurons are rare, however. We developed a protein synthesis reporter in which the coding sequence of green fluorescent protein is flanked by the 5' and 3' untranslated regions from CAMKI...
متن کاملIntra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons.
Axonal protein synthesis is a complex process involving selective mRNA localization and translational regulation. In this study, using in situ hybridization and metabolic labeling, we show that the mRNAs encoding eukaryotic translation initiation factors eIF2B2 and eIF4G2 are present in the axons of rat sympathetic neurons and are locally translated. We also report that a noncoding microRNA, mi...
متن کاملDendrites as separate compartment - local protein synthesis.
The article summarizes the most meaningful studies which have provided evidence that protein synthesis in neurons can occur not only in cell perikarya but also locally in dendrites. The presence of the complete machinery required to synthesize cytoplasmic and integral membrane proteins in dendrites, identification of binding proteins known to mediate mRNA trafficking in dendrites and the abilit...
متن کاملChemically inducible inactivation of protein synthesis in genetically targeted neurons.
Introduction Synaptic plasticity mediates a variety of physiological functions, including emotional regulation, drug addiction, and learning and memory (Goelet et al., 1986). There are two temporally distinct forms of synaptic plasticity: short-term plasticity, which lasts seconds to minutes, and long-term plasticity, which lasts hours and days (Davis and Squire, 1984). Long-term plasticity dif...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2001
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(01)00548-6